A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE(S,R)-SULFOXIMINE.
نویسندگان
چکیده
منابع مشابه
Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice.
Oxidative stress and genomic rearrangements play a role in cancer development. l-Buthionine-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting gamma-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH). We postulated that oxidative stress induced by GSH depletion might lead to genomic rearrangements, such as DNA deletions, and that...
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Taxol is a naturally occurring chemotherapeutic agent that is active against a variety of tumors. Taxol is believed to act by binding tightly to microtubules and preventing their disaggregation. Others have shown that depletion of cellular glutathione results in the disaggregation of microtubules, presumably by allowing the oxidation of some or all of the cysteine residues in tubulins. We studi...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2003
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.28.455